Why the study?
Does troglitazone improve pressure-natriuresis and renal NOx levels in insulin-resistant obese Zucker rats?
Population
Insulin-resistant obese Zucker rats (OZ) and lean Zucker rats (LZ)
Comparison
4-week treatment with troglitazone vs Untreated obese Zucker rats and lean Zucker rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Troglitazone does not restore blunted pressure-natriuresis in obese Zucker rats despite metabolic gains; leaves open nitric oxide-independent mechanisms in insulin-resistant hypertension.
Does troglitazone improve pressure-natriuresis and renal NOx levels in insulin-resistant obese Zucker rats?
Insulin resistance in obese Zucker rats is associated with abnormal pressure-natriuresis and hypertension, likely due to impaired medullary nitric oxide production.
Fujiwara et al. (1999) studied this question.
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