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July 29, 2010Molecular Biology of the CellOpen Access

A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy

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Population

Transgenic mice with muscle specific expression of various mTOR mutants and models of Rheb overexpression in…

Design

Preclinical

Authors

CGCraig A. GoodmanDeakin UniversityMMMan Hing MiuUniversity of Wisconsin–MadisonJFJohn W. FreyUniversity of Wisconsin–Madison

Discussion

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Implication

Should not change clinical practice; leaves open Rheb-mTOR targeting for human muscle hypertrophy.

Structured PICO

P
Population
Transgenic mice with muscle specific expression of various mTOR mutants and models of Rheb overexpression in skeletal muscle
I
Intervention
Overexpression of Rheb and expression of mTOR mutants
O
Outcome
Induction of skeletal muscle hypertrophysurrogate

This study provides direct genetic evidence that PI3K/PKB-independent activation of mTOR signaling via Rheb is sufficient to induce skeletal muscle hypertrophy.

Cite This Study

Goodman et al. (2010) studied this question.

synapsesocial.com/papers/6a769453d8eb58afc2bd461dhttps://doi.org/10.1091/mbc.e10-05-0454
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism2004 · 255 citations
  2. 2Signaling in Muscle Atrophy and Hypertrophy2008 · 829 citations
  3. 3Specificity and mechanism of action of some commonly used protein kinase inhibitors2000 · 4,060 citations
  4. 4Specificity and mechanism of action of some commonly used protein kinase inhibitors2000 · 3,152 citations
  5. 5mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes2010 · 158 citations