What question did this study set out to answer?

To determine whether percentage signal recovery and normalized baseline signal intensity can differentiate glioblastoma, metastasis, lymphoma, and meningioma using a DSC-MRI protocol optimized for relative cerebral blood volume accuracy.

August 1, 2019American Journal of NeuroradiologyOpen Access

Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma

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To determine whether percentage signal recovery and normalized baseline signal intensity can differentiate glioblastoma, metastasis, lymphoma, and meningioma using a DSC-MRI protocol optimized for relative cerebral blood volume accuracy.
Evaluated patients with contrast-enhancing brain lesions using 1.5T DSC-MRI with a protocol optimized for relative CBV accuracy (TR/TE = 1290/40 ms, 60° flip angle, one-quarter-dose gadobutrol preload, and single-dose bolus).
Calculated mean percentage signal recovery, relative CBV, and normalized baseline signal intensity across contrast-enhancing lesion volumes, evaluating diagnostic performance via receiver operating characteristic analysis.
Relative CBV differentiated meningioma from glioblastoma and metastasis with areas under the curve of 0.84 and 0.82, respectively.
Percentage signal recovery best differentiated primary central nervous system lymphoma from metastasis with an area under the curve of 0.81, while performing comparably to relative CBV when separating lymphoma from glioblastoma and meningioma.
Neither relative CBV nor percentage signal recovery separated glioblastoma from metastasis, but mean normalized baseline signal intensity differentiated them with 86% sensitivity and 50% specificity.

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Implication

Diagnostic study demonstrates percentage signal recovery differentiates diverse brain neoplasms in contrast-enhancing tumors, highlighting clinical utility in optimized protocols.

Cite This Study

Lee et al. (2019) studied this question.

synapsesocial.com/papers/6a76a826ee59ab58d3f6bb25 https://doi.org/10.3174/ajnr.a6153

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Implication

Diagnostic study demonstrates percentage signal recovery differentiates diverse brain neoplasms in contrast-enhancing tumors, highlighting clinical utility in optimized protocols.

Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma

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Discussion

Implication

Cite This Study

Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma

Key Points

Discussion

Implication

Cite This Study

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