May 1, 1978Journal of Clinical InvestigationOpen Access

The Role of Cyclic Adenosine Monophosphate in Adrenergic Effects on Ventricular Vulnerability to Fibrillation in the Isolated Perfused Rat Heart

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Population

Isolated perfused rat heart model

Design

Preclinical

Authors

WLWelma LubbeNorth-West University TPT. PodzuweitMax Planck Society PDP DariesUniversity of Cape Town

Discussion

Member takes

Implication

Warrants no change in clinical VF management; leaves open cAMP-mediated arrhythmogenesis as a research target.

Structured PICO

Population

Isolated perfused rat heart model

Intervention

Administration of dibutyryl cyclic AMP (DBcAMP), cAMP, theophylline, atenolol, and epinephrine

Outcome

Ventricular fibrillation threshold (VFT) and vulnerable period duration (VP)surrogate

The study demonstrates that adrenergic effects on ventricular vulnerability to fibrillation are mediated by intracellular cAMP levels in the isolated perfused rat heart.

Cite This Study

Lubbe et al. (1978) studied this question.

synapsesocial.com/papers/6a76a8374fe2e6ffd8ec1073 https://doi.org/10.1172/jci109042

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The Role of Cyclic Adenosine Monophosphate in Adrenergic Effects on Ventricular Vulnerability to Fibrillation in the Isolated Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Role of Cyclic Adenosine Monophosphate in Adrenergic Effects on Ventricular Vulnerability to Fibrillation in the Isolated Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider