What question did this study set out to answer?

To determine the effects of formalin fixation duration on transverse relaxation time (T2) and spin density in postmortem human brains to optimize MRI contrast.

November 1, 1999Acta Radiologica

Optimising Imaging Parameters for Post Mortem MR Imaging of the Human Brain

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Authors

ABAndrew M. BlamireNewcastle University JRJackson RoweWashington University in St. Louis PSPeter StylesKeele University

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Implication

Experimental study demonstrates converging T2 times and increasing spin density ratios in formalin-fixed postmortem brains, indicating spin density weighting optimizes tissue contrast.

Key Points

To determine the effects of formalin fixation duration on transverse relaxation time (T2) and spin density in postmortem human brains to optimize MRI contrast.
Examined three postmortem human brains weekly during formalin fixation from the unfixed state up to 35 days (N=3).
Calculated transverse relaxation time (T2) and spin density using standard spin-echo MRI across five echo times ranging from 20 to 100 ms.
Transverse relaxation time (T2) decreased significantly in both grey and white matter by 7 days of fixation (ANOVA, p<0.001), with grey and white matter T2 times converging through 35 days.
The grey-to-white matter spin density ratio increased from 1.19 ± 0.01 in the unfixed state to 1.54 ± 0.06 over five weeks of formalin fixation.

Cite This Study

Blamire et al. (1999) studied this question.

synapsesocial.com/papers/6a76a84ad3a6aa87c6bd51ce https://doi.org/10.3109/02841859909175593

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Implication

Experimental study demonstrates converging T2 times and increasing spin density ratios in formalin-fixed postmortem brains, indicating spin density weighting optimizes tissue contrast.

Optimising Imaging Parameters for Post Mortem MR Imaging of the Human Brain

Discussion

Member takes

Implication

Key Points

Cite This Study

Optimising Imaging Parameters for Post Mortem MR Imaging of the Human Brain

Discussion

Member takes

Implication

Key Points

Cite This Study

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