September 18, 2009Muscle & Nerve

Involvement of PI3K/Akt/TOR pathway in stretch‐induced hypertrophy of myotubes

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Population

Primary cultures of chick skeletal myotubes

Comparison

Passive cyclic stretching for 72 hours with or… vs Unstretched myotubes or stretched myotubes…

Design

Preclinical

Follow-up

72 hours

Authors

NSNobuaki SasaiSuzuka University of Medical Science NANobuhide AgataTokoha Gakuen University MIMasumi Inoue‐MiyazuAichi Medical College for Physical and Occupational Therapy

Discussion

Member takes

Implication

Cautions against clinical translation of stretch-induced hypertrophy pathways; leaves open whether PI3K/Akt/mTOR targeting alters human muscle remodeling.

Structured PICO

Population

Primary cultures of chick skeletal myotubes

Intervention

Passive cyclic stretching for 72 hours with or without PI3K/mTOR inhibitors (wortmannin or rapamycin) or MEK inhibitor (U0126)

Comparator

Unstretched myotubes or stretched myotubes without inhibitors

Outcome

Muscle hypertrophy and phosphorylation of Aktsurrogate

Cyclic stretching of skeletal myotubes induces hypertrophy via activation of the PI3K/Akt/TOR pathway.

Cite This Study

Sasai et al. (2009) studied this question.

synapsesocial.com/papers/6a76a925f6b553d308adf448 https://doi.org/10.1002/mus.21473

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Implication

Cautions against clinical translation of stretch-induced hypertrophy pathways; leaves open whether PI3K/Akt/mTOR targeting alters human muscle remodeling.

Involvement of PI3K/Akt/TOR pathway in stretch‐induced hypertrophy of myotubes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of PI3K/Akt/TOR pathway in stretch‐induced hypertrophy of myotubes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider