This review highlights the epidemiological impact and pathogenic mechanisms of HCC in NAFLD, emphasizing the need for targeted screening and preventive-therapeutic strategies.
NAFLD-HCC frequently arises without cirrhosis; leaves open optimal surveillance criteria in at-risk non-cirrhotic patients.
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. An increasing number of reports describe HCC in the setting of obesity and diabetes, two major risk factors for non-alcoholic fatty liver disease (NAFLD). The increasing incidence of these conditions and the emerging evidence of HCC in non-cirrhotic NAFLD prioritize a better understanding of NAFLD-related HCC epidemiology and pathogenesis in order to target screening policies and develop preventive-therapeutic strategies. In this review, we focus on the epidemiological impact of this condition, suggesting a possible link between HCC in cryptogenic cirrhosis and NAFLD. Furthermore, we analyse the suggested pathogenic mechanisms and the possible preventive-therapeutic strategies.
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Margini et al. (2015) studied this question.
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