What question did this study set out to answer?

To describe the physiological distribution of P-glycoprotein in normal human tissues and assess the pharmacokinetic and pharmacodynamic consequences of modulating its transporter activity.

July 1, 2001Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyOpen Access

Pharmacokinetic and Pharmacodynamic Implications of P‐glycoprotein Modulation

View Full Paper

Ask AI

Bookmark

Authors

CMChristopher MathenyGene Therapy Laboratory MLMatthew W. LambJacksonville College KBKim L. R. BrouwerUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Review demonstrates that P-glycoprotein modulation alters drug absorption, distribution, and elimination, highlighting significant pharmacokinetic interactions during concomitant therapy.

Key Points

To describe the physiological distribution of P-glycoprotein in normal human tissues and assess the pharmacokinetic and pharmacodynamic consequences of modulating its transporter activity.
Reviewed scientific literature regarding P-glycoprotein expression and function across normal physiological barrier and clearance organs.
Analyzed the mechanistic impacts of pharmacological P-glycoprotein inhibitors and inducers on the disposition of co-administered substrate medications.
P-glycoprotein is constitutively expressed in key tissues regulating drug absorption (intestines), site-of-action distribution (central nervous system, leukocytes), and systemic elimination (liver, kidneys).
Pharmacological inhibition or induction of P-glycoprotein significantly alters substrate bioavailability, tissue penetration, and clearance, driving critical drug-drug interactions.

Cite This Study

Matheny et al. (2001) studied this question.

synapsesocial.com/papers/6a76aaa4a7498e5110adf601 https://doi.org/10.1592/phco.21.9.778.34558

View Full Paper

Ask AI

Bookmark

Implication

Review demonstrates that P-glycoprotein modulation alters drug absorption, distribution, and elimination, highlighting significant pharmacokinetic interactions during concomitant therapy.

Pharmacokinetic and Pharmacodynamic Implications of P‐glycoprotein Modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacokinetic and Pharmacodynamic Implications of P‐glycoprotein Modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider