The enzymic formation of aminoacetone from threonine and its further metabolism

Whether the chelate as a whole is incorporated into the cells or whether there is a partial release of the metal in the system, which then undergoes 'normal' metabolism, is not known. The fact that the changes observed in the activities of the bones with the diethyldithiocarbamate chelate are qualitatively quite similar to those with the tracer alone rather suggests the second possibility. SUMMARY 1. When administered alone to albino rats there is a rapid passage of the 59Fe from the blood into the bones and a subsequent slow retransfer; This process is presumably a normal occurrence in iron metabolism. At all times, the blood and the bones account for most of the activity. The activity in the liver remains fairly constant at a low level. The excretion, initially negligible, becomes appreciable subsequently.