Population
Human coronary artery vascular smooth muscle cells (VSMCs)
Comparison
Pharmacological and ionic manipulation vs Baseline or control conditions
Design
Preclinical
Authors
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STOCs in coronary VSMCs depend on BKCa and Na+/Ca2+ exchange; hypothesis-generating for vasoregulation, requires in vivo confirmation before clinical consideration.
Spontaneous transient outward potassium currents in human coronary vascular smooth muscle cells are generated by BKCa channels and regulated by intracellular Na+ and calcium store refilling, likely via reverse-mode Na+/Ca2+ exchange.
Bychkov et al. (1997) studied this question.
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