Population
Porcine papillary muscle fibers with native regulatory light chain replaced by human ventricular RLC tagged…
Design
Preclinical
Authors
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Not ready for clinical use; extends Huxley-Simmons model with a method to quantify light-chain mutation effects on cardiac myosin strain.
Single molecule orientation detection of myosin in porcine papillary muscle fibers reveals discretized power-stroke substates and quantifies lever-arm shear strain, providing a method to detect impacts of light chain mutations.
Burghardt et al. (2011) studied this question.
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