Population
Biophysical mathematical model of a murine cardiac Purkinje cell
Comparison
Varying the effective cytosolic Ca diffusion rate vs Control values
Design
Preclinical
Authors
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Model shows Ca²⁺ diffusion shapes Purkinje AP abnormalities; leaves open mechanistic role in human arrhythmogenesis.
Cytosolic calcium diffusion waves play a significant role in shaping action potentials of Purkinje cells via NCX current, providing mechanistic insights into their arrhythmogenicity.
Limbu et al. (2016) studied this question.
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