February 1, 1989Journal of VirologyOpen Access

Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

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Population

HeLa cells infected by adenovirus deletion mutants (H2dl808 or H5dl1004) and wild-type virus

Comparison

Deletion of adenovirus early region E4 vs Wild-type adenovirus

Design

Preclinical

Authors

ASAbby B. SandlerNational Institutes of Health GKGary KetnerUppsala University

Discussion

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Implication

E4 may stabilize late adenovirus nuclear RNAs; hypothesis-generating in animal models and requires human validation.

Structured PICO

Population

HeLa cells infected by adenovirus deletion mutants (H2dl808 or H5dl1004) and wild-type virus

Intervention

Deletion of adenovirus early region E4 (H2dl808 and H5dl1004 mutants)

Comparator

Wild-type adenovirus

Outcome

Accumulation and stability of late nuclear RNAs and viral DNAsurrogate

Adenovirus early region 4 products are essential for the stability of viral RNA in the nucleus, highlighting a novel aspect of viral gene expression regulation.

Cite This Study

Sandler et al. (1989) studied this question.

synapsesocial.com/papers/6a76ba10ee59ab58d3f6c030 https://doi.org/10.1128/jvi.63.2.624-630.1989

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Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider