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October 20, 2016Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase

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Why the study?

Does NADPH oxidase inhibition or aerobic exercise improve microvascular endothelial function and reduce reactive oxygen species in sedentary obese humans?

Population

42 young, sedentary men and women divided into lean, intermediate, and obese groups.

Comparison

Perfusion of apocynin via microdialysis, and an… vs Lean and intermediate subjects, and…

Design

Cohort

Follow-up

8 weeks

Authors

JFJustin D. La FavorFlorida State UniversityGDGabriel S. DubisEast Carolina UniversityHYHuimin YanWashington University in St. Louis

Discussion

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Overview

Aerobic exercise may alleviate obesity-linked microvascular dysfunction; leaves open whether NOX-targeted therapies improve outcomes.

Structured PICO

Does NADPH oxidase inhibition or aerobic exercise improve microvascular endothelial function and reduce reactive oxygen species in sedentary obese humans?

P
Population
42 young, sedentary men and women divided into lean (body mass index 18-25; n=14), intermediate (body mass index 28-32.5; n=13), and obese (body mass index 33-40; n=15) groups.
I
Intervention
Perfusion of apocynin (an NADPH oxidase inhibitor) via microdialysis, and an 8-week aerobic exercise intervention.
C
Comparator
Lean and intermediate subjects, and pre-intervention baseline.
O
Outcome
Microvascular endothelial function (acetylcholine-stimulated nutritive blood flow) and interstitial hydrogen peroxide (H2O2) and superoxide levels in the vastus lateralis.surrogate

NADPH oxidase mediates microvascular endothelial dysfunction in obesity, which can be effectively reversed by aerobic exercise training.

Cite This Study

Favor et al. (2016) studied this question.

synapsesocial.com/papers/6a76bdc2576efb0ddaf6cae8https://doi.org/10.1161/atvbaha.116.308339
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Also Consider

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  1. 1Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome2014 · 137 citations
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  4. 4Microcirculation in Hypertension2001 · 633 citations
  5. 5Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease2005 · 276 citations