A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio‐Cerebral Vascular Diseases

Figure 1. Workflow of network pharmacology analysis.

Figure 2. Linkage of target compounds and target genes. (a) The network of herbal medicine compound in SM and RP. The yellow diamond is SM and RP, and the blue pentagon is the active ingredient. (b, c) The component-target diagram of SM and RP. The yellow hexagon is the active ingredients, and the green ellipse is the target. (d) The Veeny diagram of the target genes for SM and RP.

Figure 3. KEGG pathways and GO analysis by David database: (a) GO analysis of candidate targets. Database showed the five remarkably enriched items in the biological processes (BP), cell component (CC), and molecular function (MF); (b) KEGG pathways of target genes; (c) main functional annotation clusters by Biocarta analysis.

Figure 4. Component-target-path network. The blue diamond represents the target, the red diamond represents the cotarget, the yellow hexagon represents the SM active component, the green hexagon represents the RP active component, and the pink rectangle represents the pathway.

Figure 5. Protein-protein interaction (PPI) networks of active ingredients of SM and RP for the treatment of CCVDs. Each node represents the relevant gene, and the edge means line thickness indicates the strength of data support. PPI network map of active components and diseases.