Why the study?
Does early administration of beta-blockers reduce in-hospital mortality in adults with acute or suspected MI?
Population
18 RCTs pooling 72,249 adults with acute or suspected myocardial infarction within 24 hours of onset of…
Comparison
Intravenous or oral beta-blockers administered… vs Standard medical therapy with or without placebo.
Design
Meta-analysis
Follow-up
in-hospital
Authors
Loading...
Early beta-blockers do not reduce in-hospital mortality in acute MI; confirms neutral effect on primary endpoint and supports caution for shock risk.
Does early administration of beta-blockers reduce in-hospital mortality in adults with acute or suspected MI?
Early administration of beta-blockers in patients with acute or suspected MI does not significantly improve in-hospital mortality and may increase the risk of cardiogenic shock.
Brandler et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: