Why the study?
The effect of comorbid cardiometabolic diseases, including diabetes, heart diseases, and stroke, on dementia remains unclear.
Does an active lifestyle mitigate the risk of dementia in older adults with cardiometabolic diseases?
Does an active lifestyle mitigate the risk of dementia in older adults with cardiometabolic diseases?
An active lifestyle, including leisure activities and social integration, can mitigate the increased risk of dementia associated with cardiometabolic diseases in older adults.
CMDs were associated with higher dementia risk in older adults; leaves open whether active lifestyle attenuates this in cardiometabolic patients.
INTRODUCTION: The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. METHODS: A cohort of 2648 dementia-free adults aged ≥60 years was followed up for 12 years. An active lifestyle was defined in accordance with the engagement in leisure activities and/or a social network. Cox models were used in data analysis. RESULTS: The multiadjusted hazard ratio (HR, 95% confidence interval) of dementia was 1.41 (1.07-1.86) for one, 2.38 (1.58-3.59) for two, and 4.76 (2.04-11.13) for three CMDs. In joint exposure analysis, the HR of dementia was 3.36 (2.14-5.30) for participants with CMDs plus an inactive lifestyle and 1.32 (0.95-1.84) for those with CMDs plus an active lifestyle (reference: no CMDs plus active lifestyle). An active lifestyle delayed dementia onset by 3.50 years in people with CMDs. DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk.
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Wang et al. (2019) studied this question.