Population
Wild-type (TK+/+) and tissue kallikrein-knockout (TK-/-) mice, and bradykinin B2 receptor knockout mice
Comparison
In vitro perfusion of carotid arteries with… vs TK(-/-) arteries compared to TK(+/+) arteries
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open the vascular KKS role in human flow-mediated dilation.
The vascular kallikrein-kinin system actively contributes to flow-dependent dilation in carotid arteries via activation of B2 receptors coupled to endothelial NO release.
Bergaya et al. (2001) studied this question.
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