Effects of Levosimendan on the Energy Balance: Preclinical and Clinical Evidence
Population
Patients with acute heart failure syndromes, ischemic heart disease, cardiogenic or septic shock, and those…
Design
Review
Authors
Discussion
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Member takes
Implication
May inform levosimendan selection in acute HF or shock; leaves open RCTs confirming ischemic cardioprotection.
Structured PICO
P
Population
Patients with acute heart failure syndromes, ischemic heart disease, cardiogenic or septic shock, and those in the perioperative phase of cardiac surgery, as well as preclinical models
I
Intervention
Levosimendan
Levosimendan improves myocardial function without increasing oxygen consumption, offering potential benefits in acute heart failure, shock, and perioperative cardiac surgery.
Cite This Study
Nieminen et al. (2009) studied this question.