High-resolution X-ray microtomography can successfully detect and quantify dose-dependent emphysema in live mice.
Supports noninvasive emphysema quantification in murine models; hypothesis-generating for translational imaging research.
High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.
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Postnov et al. (2005) studied this question.
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