December 1, 2002Hypertension

Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

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Population

Spontaneously hypertensive rats (SHR) and normotensive control Wistar-Kyoto (WKY) rats

Comparison

Candesartan (AT1 receptor antagonist) vs Normotensive WKY rats and untreated SHR

Design

Preclinical

Authors

YNYoshiro NaitoMukogawa Women's University TTTakeshi TsujinoKobe Medical Center YFYoshio FujiokaKobe Gakuin University

Discussion

Member takes

Implication

Augmented circadian RAS oscillations in hypertensive rat models support chronotherapy trials; leaves open translation to human hypertension.

Structured PICO

Population

Spontaneously hypertensive rats (SHR) and normotensive control Wistar-Kyoto (WKY) rats

Intervention

Candesartan (AT1 receptor antagonist)

Comparator

Normotensive WKY rats and untreated SHR

Outcome

Circadian mRNA expression of renin, angiotensinogen, ACE, and angiotensin type 1a (AT1a) and type 2 (AT2) receptors in the heartsurrogate

Cardiac renin-angiotensin system genes exhibit augmented diurnal variations in spontaneously hypertensive rats, which may explain discrepancies in prior gene expression studies.

Cite This Study

Naito et al. (2002) studied this question.

synapsesocial.com/papers/6a76d9afe29fd788c9f6e01d https://doi.org/10.1161/01.hyp.0000039960.66987.89

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Augmented circadian RAS oscillations in hypertensive rat models support chronotherapy trials; leaves open translation to human hypertension.

Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider