Genome sequencing of microorganisms has become increasingly important for outbreak investigation and pathogen surveillance in recent years, proving to be invaluable in these areas due to its high resolution. However, its applications in clinical settings are still limited [1]. To integrate genome sequencing, in particular whole genome sequencing (WGS), into patient care, we need to overcome several challenges. These include technical limitations due to the complexity and reproducibility of the large amount of sequencing data produced, which calls for advanced IT solutions; the lack of standardized and automated wet-lab protocols; high costs per sample when processing only a few samples in clinical diagnostics; and the lack of unified reporting of results [2]. Achieving this integration demands focused dialogues, a willingness to evolve and innovate, and interdisciplinary solutions. A united community can standardize efforts, facilitate resource and data sharing, and amplify collective advancements.
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Germuskova et al. (2024) studied this question.
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