Review highlights recent advancements in stereoselective O-glycosylation methodologies for glycans, indicating new pathways for carbohydrate-based therapies.
Stereoselective chemical glycosylation represents the key steps for the construction of structurally well-defined glycans and glycoconjugates, which are essential for interrogating their biological functions and developing carbohydrate-based medicines. This review highlights advances in the past two years in stereoselective O -glycosylation methodologies, including THF-modulated glycosylation, donor-derived auxiliary group-mediated glycosylation, catalyst-mediated glycosylation, and non-assisted aglycon transfer glycosylation.
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Zhou et al. (2026) studied this question.
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