Acute Kidney Injury Induces Neurological Impairment Through Early Blood-Brain Barrier Disruption and Endothelial Transcytosis in Mice

Key Points

This study aims to investigate the effects of acute kidney injury on brain health and blood-brain barrier permeability in a mouse model.
Mouse model of unilateral renal ischemia-reperfusion injury with or without acute kidney injury in 7-week-old male C57Bl/6J mice.
Neurologic impairment assessed using modified neurologic severity score and motricity evaluations.
Cerebral extravasation quantified by Evans blue and 68Ga-DTPA PET/CT imaging, with further analysis via immunohistochemistry and electron microscopy.
Mice with acute kidney injury exhibited significant neurologic impairment and decreased spontaneous motricity.
Cerebral Evans blue extravasation indicated increased blood-brain barrier permeability in AKI mice compared to controls.
68Ga-DTPA PET/CT imaging confirmed blood-brain barrier disruption in AKI models.

We only have this paper's title and publication details.

Demonstrates increased neurological impairment in mice with acute kidney injury, indicating potential pathways for cognitive decline.

No takes yet. Share an insight, caveat, or question.

Bobot et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Share