Key result
Elevated triglycerides linked to ~63% higher odds of premature coronary heart disease at high altitude.
Why the study?
Risk profiles of premature coronary heart disease among high-altitude acute coronary syndrome populations remain poorly characterized.
Observational (n=467)
No
Odds Ratio: 1.625 (95% CI 1.482–1.809)
p-value: p=0.001
In high-altitude populations, diabetes, triglycerides, WBC, D-dimer, and lower SpO2 are independent predictors of premature coronary heart disease in patients presenting with acute coronary syndrome.
These predictors were associated with PCHD in high-altitude residents; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Risk profiles of premature coronary heart disease (PCHD, ≤45 years) among high-altitude acute coronary syndrome (ACS) populations remain poorly characterized. This study explored clinical features and independent predictors of early-onset ACS in Lhasa. Methods: We retrospectively enrolled 467 first-ACS patients (1 July 2022–30 June 2024). Patients were further dichotomized into PCHD and non-PCHD groups for comparison. Univariable and multivariable logistic regression identified PCHD risk factors. Results: Compared with non-PCHD patients, PCHD patients featured higher proportions of male non-Tibetans, higher smoking and alcohol consumption rates, lower prevalence of hypertension and diabetes, and elevated SpO2 (all p < 0.05). They had significantly higher CHOL, TG, LDL-C, UA and Hb (all p < 0.05), accompanied by lower WBC, PLT and D-dimer (all p < 0.001). Multivariate regression confirmed diabetes mellitus (OR = 1.158, p = 0.014), TG (OR = 1.625, p < 0.001), WBC (OR = 1.995, p = 0.007), D-dimer (OR = 2.841, p = 0.043) and SpO2 (OR = 0.937, p = 0.019) as independent predictors of PCHD. Conclusions: Integrated monitoring of glucose, lipids, hypoxia and thromboinflammatory biomarkers may supply preliminary auxiliary reference for early prevention of PCHD in local highland youth, while large multi-center verification is still needed to confirm its clinical value.
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Yu et al. (2026) conducted an observational in Acute Coronary Syndrome (ACS) (n=467). Clinical and laboratory risk factors (e.g., triglycerides, D-dimer, WBC, diabetes, SpO2) vs. Non-premature coronary heart disease (>45 years) was evaluated on Independent predictors of premature coronary heart disease (PCHD, ≤45 years) (OR 1.625, 95% CI 1.482-1.809, p=0.001). Elevated triglycerides (OR 1.625), D-dimer, white blood cell count, diabetes mellitus, and lower SpO2 were identified as independent predictors of premature coronary heart disease in high-altitude residents.
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