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August 8, 2026Genes & DevelopmentOpen Access

Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology

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Authors

CCCaleb ChengRPRüya PakkanACArul M. Chinnaiyan

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Overview

Review examines lysosomal metabolism's role in pancreatic cancer and implications for therapy.

Key Points

  • This review aims to explore the role of lysosomal metabolism in pancreatic cancer and its interactions with host physiology.
  • Reviewed current tools and concepts for studying lysosomal function in pancreatic cancer.
  • Integrated insights from systemic metabolism and dietary interventions.
  • Outlined therapeutic approaches based on lysosome dependence in pancreatic cancer.
  • Lysosomal pathways enhance nutrient acquisition, immune evasion, and tumor metabolism in pancreatic cancer.
  • Blockade of autophagy/lysosomal function shows potent antitumor effects in preclinical models.
  • Limited benefit observed in clinical trials using lysosomotropic agents, indicating challenges in targeting strategies.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a76db01f12abadc79815e94https://doi.org/10.1101/gad.353702.126
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