Hepatitis B resistance in Iran.

Emerging new medications in the treatment of HBV produces hope and promises for curing of HBV. Over the past decade, the development of oral nucleoside/nucleotide analogs (NAs) with favorable potencies and tolerabilities has led to substantial advances in chronic hepatitis B (CHB) therapy. The oral anti-HBV agents currently approved are lamivudine, adefovir dipivoxil , entecavir , telbivudine, clevudine, and tenofovir. Treatment algorithms have been developed to assist in identification of suitable candidates for treatment and to determine and initiate appropriate treatment . In this review the problem of drug resistance in the course of chronic hepatitis B treatment are discussed in detail from both aspects of clinical and genetics.