September 11, 1995FEBS LettersOpen Access

The difference between ADP‐beryllium fluoride and ADP‐aluminium fluoride complexes of the spin‐labeled myosin subfragment 1

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Population

Spin-labeled myosin subfragment 1 (S1)

Comparison

ADP-beryllium fluoride complex formation vs ADP-aluminium fluoride or other phosphate…

Design

Preclinical

Authors

Discussion

Distinguishes myosin ATPase transition states structurally; extends models but leaves open relevance to cardiac contractility or therapies.

Population

Spin-labeled myosin subfragment 1 (S1)

Intervention

ADP-beryllium fluoride (ADP-BeFx) complex formation

Comparator

ADP-aluminium fluoride (ADP-AlF4) or other phosphate analogues (orthovanadate)

Outcome

Local conformational changes in the region of Cys-707 measured by Electron paramagnetic resonance (EPR) spectroscopysurrogate

S1-ADP-AlF4 and S1-ADP-BeFx complexes represent structural analogues of different transition states of the myosin ATPase cycle.

Ponomarev et al. (1995) studied this question.

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Distinguishes myosin ATPase transition states structurally; extends models but leaves open relevance to cardiac contractility or therapies.