Population
15 isolated rabbit sinus node preparations
Comparison
Atrial pacing with decreasing pacing cycle… vs Control values (cessation of drive)
Design
Preclinical
Authors
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May caution SNRT interpretation after rapid pacing; leaves open human translation and mechanisms.
In isolated rabbit sinus nodes, rapid atrial pacing depresses phase 4 depolarization dependent on the prior rate of propagated beats, indicating sinus node recovery time is a complex interaction between conduction and impulse formation.
Steinbeck et al. (1980) studied this question.
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