Population
In vitro models, COS-7 cells expressing EGFP-Kv4.2 fusion protein, and hippocampal area CA1
Design
Preclinical
Authors
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May guide Kv4.2 regulation studies in myocytes and neurons; leaves open functional consequences in vivo.
The study identifies Thr38 and Ser552 as specific sites where PKA phosphorylates Kv4.2 channels, providing a molecular basis for their regulation in ventricular myocytes and neurons.
Anderson et al. (2000) studied this question.
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