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January 1, 2009Korean Journal of PediatricsOpen Access

Bosentan significantly inhibited right ventricular hypertrophy on day 28 (RV/[LV+S]: 0.49±0.09 vs 0.71±0.10, P<0.05) and attenuated medial wall thickness increase (47.09±10.48% vs 49.96±10.06%, P<0.05).

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Why the study?

Does bosentan reduce pulmonary vascular hypertrophy and right ventricular hypertrophy in rats with MCT-induced pulmonary hypertension?

Population

Sprague-Dawley rats with monocrotaline (MCT)-induced pulmonary hypertension

Comparison

Bosentan (20 mg/kg/day) following MCT injection vs MCT-treated rats and control rats

Design

Preclinical

Follow-up

7, 14, or 28 days

Authors

KLKyoung Ah LimJSJung Yun ShimSCSang-Ho Cho

Discussion

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Overview

Hypothesis-generating in MCT-PH rats; leaves open whether bosentan benefits human pulmonary hypertension.

Structured PICO

Does bosentan reduce pulmonary vascular hypertrophy and right ventricular hypertrophy in rats with MCT-induced pulmonary hypertension?

P
Population
Sprague-Dawley rats with monocrotaline (MCT)-induced pulmonary hypertension
I
Intervention
Bosentan (20 mg/kg/day) following MCT injection
C
Comparator
MCT-treated rats (no bosentan) and control rats (subcutaneous saline injection)
O
Outcome
Pulmonary vascular morphology changes (right ventricular hypertrophy, medial wall thickness of peripheral pulmonary arteries, number of intra-acinar muscular arteries)surrogate

Bosentan at intermediate doses inhibits lung vascular and right ventricular hypertrophy in a rat model of MCT-induced pulmonary hypertension.

Cite This Study

Lim et al. (2009) studied this question.

synapsesocial.com/papers/6a76ea34e539f649abf6cffdhttps://doi.org/10.3345/kjp.2009.52.6.689
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats1997 · 96 citations
  2. 2Gene Expression of Endothelin-1 and Endothelin Receptor A on Monocrotaline-Induced Pulmonary Hypertension in Rats After Bosentan Treatment2010 · 24 citations
  3. 3Effects of Bosentan Treatment on Angiotensin Converting Enzyme in Monocrotaline Induced Pulmonary Hypertension Rats2011 · 1 citations
  4. 4Roles of Endothelin ETA and ETB Receptors in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension2004 · 41 citations
  5. 5Optimization of tissue targeting properties of macitentan, a new dual endothelin receptor antagonist, improves its efficacy in a rat model of pulmonary fibrosis associated with pulmonary arterial hypertension2011