Why the study?
Increased ERRγ expression has been linked to metabolic inflexibility in diabetic cardiomyopathy, suggesting sustained expression of this nuclear receptor might cause cardiac pathogenesis.
Population
Mice
Comparison
Cardiac-specific overexpression of ERRγ
Design
Preclinical animal study
Authors
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Animal data link ERR loss to cardiac dysfunction; leaves open therapeutic targeting in human HF.
Cardiac-specific overexpression of ERRγ in mice induces severe heart dysfunction, dilated cardiomyopathy, and early lethality, suggesting a pathogenic role in cardiac responses.
Lasheras et al. (2021) studied this question.
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