December 31, 2009PLoS ONEOpen Access

Loss of Smyhc1 or Hsp90α1 Function Results in Different Effects on Myofibril Organization in Skeletal Muscles of Zebrafish Embryos

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Population

Zebrafish embryos

Comparison

Gene-specific knockdown of myosin heavy chain 1… vs Loss of Hsp90alpha1 function

Design

Preclinical

Authors

Discussion

Highlights Hsp90alpha1's broader sarcomere role in zebrafish; extends myosin-assembly models but leaves open mammalian and clinical relevance.

Population

Zebrafish embryos

Intervention

Gene-specific knockdown of myosin heavy chain 1 (myhc1) or treatment with myosin ATPase inhibitor BTS (N-benzyl-p-toluene sulphonamide)

Comparator

Loss of Hsp90alpha1 function (knockdown or mutation)

Outcome

Organization of sarcomeric structures (thick and thin filaments, M- and Z-lines)surrogate

Hsp90alpha1 plays a broader role in the assembly and organization of sarcomeric structures beyond simply mediating myosin folding and assembly.

Codina et al. (2009) studied this question.

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Highlights Hsp90alpha1's broader sarcomere role in zebrafish; extends myosin-assembly models but leaves open mammalian and clinical relevance.