High-Intensity Training Improves Plasma Glucose and Acid-Base Regulation During Intermittent Maximal Exercise in Type 1 Diabetes

In individuals without diabetes, high-intensity exercise (HIE) training may reduce (1) the characteristic postexercise rise in plasma glucose with HIE (2-4) and reduces (5,6) the marked acid-base balance perturbations (5-8). In type 1 diabetes, continuous HIE induces sustained hyperglycemia (9,10), while very brief intermittent HIE may reduce hyperglycemia (11). Acid-base disturbances during exercise may be heightened in type 1 diabetes (12-14). Effects of HIE training on glycemia and acid-base balance during intermittent HIE in type 1 diabetes are unknown; thus, despite the potential clinical importance of such exercise, there is no evidence on which to base patient guidelines. The aim of the present study was thus to investigate the effects of HIE training on glycemia and acid-base regulation during intermittent HIE in type 1 diabetes.