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June 17, 2020Journal of Clinical MedicineOpen Access

Sacubitril/Valsartan Improves Autonomic Function and Cardiopulmonary Parameters in Patients with Heart Failure with Reduced Ejection Fraction

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Why the study?

Heart rate recovery predicts mortality in cardiovascular disease, but the effects of sacubitril/valsartan on heart rate recovery and its correlation with cardiopulmonary indexes in HFrEF required evaluation.

Does sacubitril/valsartan improve autonomic function and cardiopulmonary parameters in patients with HFrEF?

Population

134 HFrEF outpatients

Comparison

Sacubitril/valsartan therapy assessed before and after treatment

Design

Single-arm prospective study

Follow-up

12 months

Authors

FGFrancesco GiallauriaHeart Failure & TransplantGVGiuseppe VitaleCTO HospitalMPMario PacileoPreventive Cardiology

Discussion

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Member takes

Overview

S/V may improve HRR in HFrEF; hypothesis-generating observational data leave open confirmation in randomized trials.

Structured PICO

Does sacubitril/valsartan improve autonomic function and cardiopulmonary parameters in patients with HFrEF?

P
Population
134 patients with heart failure with reduced ejection fraction (HFrEF) admitted to outpatient services, mean age 57.9 ± 9.6 years, 87% male.
I
Intervention
Sacubitril/valsartan administered according to guidelines, up-titrated every 4 weeks when tolerated, for 12 months.
O
Outcome
Changes in heart rate recovery (HRR) and cardiopulmonary indexes (LVEF, VO2peak, VE/VCO2 slope) at 12-month follow-up.surrogate

Sacubitril/valsartan therapy significantly improves autonomic function, functional capacity, and ventilation parameters in patients with HFrEF over 12 months.

Cite This Study

Giallauria et al. (2020) studied this question.

synapsesocial.com/papers/6a76ee8ee29fd788c9f6ef3ehttps://doi.org/10.3390/jcm9061897
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