Why the study?
Does the muscle pump enhance blood flow in exercising skeletal muscle during maximal pharmacological vasodilation?
Population
Mongrel dogs (n = 7), instrumented for measurement of hindlimb blood flow
Comparison
Continuous intra-arterial infusion of adenosine… vs Continuous intra-arterial infusion of saline…
Design
Preclinical
Authors
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Supports vasodilation over muscle pump for exercise hyperemia; leaves open translation to human physiology.
Does the muscle pump enhance blood flow in exercising skeletal muscle during maximal pharmacological vasodilation?
The hyperemic response to exercise is primarily attributable to vasodilation in the skeletal muscle vasculature rather than the muscle pump effect.
Hamann et al. (2003) studied this question.
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