Not generally harmful: The antimicrobial and hemolytic activity of amphiphilic β-homo (β-H) peptides with the general formula H-(β-HAla-β-HLys-β-HPhe)-OH (see schematic representation) were investigated to unravel their potential for applications in medicinal chemistry. Only moderate activities were found for some of the peptides tested, critically depending on the side-chain composition of the amphiphilic helix.
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Arvidsson et al. (2001) studied this question.