Key result
This review summarizes the pharmacology, clinical trials, and practical aspects of using riociguat for the treatment of pulmonary arterial hypertension.
Why the study?
Attempting to restore pulmonary artery functionality is a hallmark of care in PAH, leading to the clinical evaluation and practical use of riociguat.
What is the role of riociguat in the treatment of patients with pulmonary arterial hypertension?
What is the role of riociguat in the treatment of patients with pulmonary arterial hypertension?
This review summarizes the pharmacology, clinical trial evidence, and practical considerations for using riociguat in patients with pulmonary arterial hypertension.
Supports riociguat use in PAH with practical insights; leaves open needs for updated comparative trials.
Pulmonary hypertension (PH) is a broad term describing the mean pulmonary artery pressure, as measured by right heart catheterization, exceeds 20mmHg. Pulmonary arterial hypertension (PAH) exists when PH is accompanied by a normal wedge pressure and elevated pulmonary vascular resistance. PAH is typified by dysmorphic and dysfunctional pulmonary arterial vasculature. Attempting to restore the functionality of the pulmonary artery is a hallmark of care to the PAH patient. Riociguat is a powerful stimulator of soluble guanylate cyclase and increases blood flow through the pulmonary arteries by dilating vascular smooth muscle cells. This review examines the pharmacology of riociguat, the fundamental clinical trials applying it to PAH patients, practical aspects when selecting its use, and future directions for its utilization.
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Mihalek et al. (2022) conducted a review in Pulmonary arterial hypertension. Riociguat was evaluated. This review summarizes the pharmacology, clinical trials, and practical aspects of using riociguat for the treatment of pulmonary arterial hypertension.
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