Key result
Neutrophil/lymphocyte ratio was significantly higher in patients with CKD Stage 3-4 compared to healthy controls (P<0.01) and correlated with 24-hour urine protein (r=0.311, P=0.004).
Why the study?
Does neutrophil/lymphocyte ratio or mean platelet volume correlate with inflammation and proteinuria in patients with CKD Stage 3-4?
Case-Control (n=83)
Does neutrophil/lymphocyte ratio or mean platelet volume correlate with inflammation and proteinuria in patients with CKD Stage 3-4?
p-value: p=<0.01
NLR, but not MPV, is elevated in CKD Stage 3-4 and correlates with proteinuria and inflammation, suggesting it may serve as a marker for atherosclerosis risk in this population.
NLR may mark inflammation in moderate CKD; leaves open its prognostic value pending prospective validation.
Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD). In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4. Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls. Fifty-three patients and 30 healthy controls were included in the study. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study. Biochemistry values and hemograms were recorded for all patients and for control group. NLR was calculated. The relationship between MPV/NLR and protein, fibrinogen, and proteinuria was evaluated. Our study showed a statistically significant difference between CKD group and healthy control (HC) group in uric acid, fibrinogen, C-reactive protein, and NLR values (P <0.01, P <0.01, P = 0.01, P <0.01, respectively). No statistically significant difference was found between CKD and HC groups for MPV (P = 0.307). Correlation analysis revealed a statistically significant relationship between NLR and creatinine (P <0.00, r = 0.571), uric acid (P <0.00, r = 0.436), glomerular filtration rate (P <0.00, r = -0.418), 24 h urine protein (P = 0.004, r = 0.311), and 24 h urine microalbumin (P = 0.001, r = 0.354). A statistically significant relationship was detected between MPV and platelet count (P <0.001, r = -0.422), age (P = 0.004, r = -0.312), uric acid (P = 0.04, r = -0.226), and fibrinogen (P = 0.023, r = -0.249). Whereas, a statistically significant relationship was detected between NLR and microalbuminuria/proteinuria, there was no statistically significant relationship between MPV and microalbuminuria/proteinuria. Our study showed that the NLR is high in CKD group and is correlated with uric acid and proteinuria, which are known to be associated with atherosclerosis, in patients with CKD. NLR may be a determinant of inflammation and atherosclerosis in patients with CKD.
No takes yet. Share an insight, caveat, or question.
Sevinç et al. (2017) conducted a case-control in Chronic kidney disease Stage 3-4 (n=83). Chronic kidney disease Stage 3-4 vs. Healthy controls was evaluated on Differences in neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV) and their correlations with inflammation and proteinuria (p=<0.01). Neutrophil/lymphocyte ratio was significantly higher in patients with CKD Stage 3-4 compared to healthy controls (P<0.01) and correlated with 24-hour urine protein (r=0.311, P=0.004).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: