Key result
Newborns carrying the C allele of the NPPB rs198389 polymorphism had significantly lower left ventricular mass indexed to body surface area compared to TT homozygotes (41.76 vs. 48.31 g/m2).
Why the study?
Does genetic variation in the natriuretic peptide system (NPPA, NPPB, NPPC genes) affect left ventricular mass and blood pressure in healthy newborns?
Cross-Sectional (n=206)
Does genetic variation in the natriuretic peptide system (NPPA, NPPB, NPPC genes) affect left ventricular mass and blood pressure in healthy newborns?
Absolute Event Rate: 41.76% vs 48.31%
p-value: p=0.044
Genetic variation in the NPPB gene is associated with modulation of left ventricular mass, and NPPA/NPPB polymorphisms are associated with blood pressure in healthy newborns.
No immediate clinical implications for newborn assessment; hypothesis-generating for NPPB effects on early cardiac development.
BACKGROUND: The natriuretic peptides play a key role in the modulation of left ventricular mass (LVM) and blood pressure (BP). We hypothesised that NPPA (natriuretic peptide precursor A gene), NPPB (natriuretic peptide precursor B gene), and NPPC (natriuretic peptide precursor C gene) are candidate genes possibly involved in the development or modulation of LVM at early life. AIM: To assess the relationship between NPPA, NPPB, and NPPC gene polymorphisms with LVM and BP in newborns. METHODS: A total of 206 healthy newborns were studied by two-dimensional M-mode echocardiography. The polymorphisms NPPA rs5065, NPPB rs198389, and NPPC rs5268 were characterised. RESULTS: Newborns carrying the C allele of the NPPB polymorphism had significantly lower LVM/body surface area (BSA) and LVM/body weight (BW) values when compared with newborns' homozygotes for the T allele (41.76 g/m2 vs. 48.31 g/m2, p adjusted = 0.044 and 2.78 g/kg vs. 3.26 g/kg, p adjusted = 0.031, respectively). An association was observed between NPPA genotype and systolic BP, diastolic BP, and mean arterial pressure ≥ 90th percentile (p = 0.029, p = 0.0048, p = 0.004, respectively). Also an association was observed for systolic BP ≥ 90th percentile for NPPB (p = 0.016). CONCLUSIONS: The present study shows that the NPPB gene polymorphism is associated with modulation of LVM in newborns. The NPPA and NPPB gene polymorphisms are associated with BP.
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Gorący et al. (2015) conducted a cross-sectional in Healthy newborns (n=206). NPPB rs198389 C allele vs. NPPB rs198389 TT homozygotes was evaluated on Left ventricular mass indexed to body surface area (LVM/BSA) (p=0.044). Newborns carrying the C allele of the NPPB rs198389 polymorphism had significantly lower left ventricular mass indexed to body surface area compared to TT homozygotes (41.76 vs. 48.31 g/m2).
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