Key result
Natriuretic peptide gene cluster polymorphisms link to NT-proBNP levels, demonstrating ~15% heritability.
Why the study?
Investigating genetic sources of inter-individual heterogeneity in circulating NT-proBNP levels could improve identification of individuals at risk of future cardiovascular disease.
Cohort (n=1,555)
Natriuretic peptide polymorphisms are associated with NT-proBNP levels, diastolic function, and metabolic features, suggesting a genetic role in the early stages of cardiovascular and metabolic disease.
No takes yet. Share an insight, caveat, or question.
NT-proBNP thresholds should remain unchanged in practice; leaves open genetic contributions to early cardiovascular and metabolic risk.
Xhaard et al. (2021) reported a cohort. Natriuretic peptide polymorphisms was evaluated on Heritability of circulating NT-proBNP levels and genome-wide association. Natriuretic peptide polymorphisms in the MTHFR-CLCN6-NPPA-NPPB-C1orf167 cluster were significantly associated with NT-proBNP levels, which demonstrated a heritability of 15%.
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