Key result
NPPA/NPPB CACGC haplotype linked to ~94% higher NT-proBNP and increased BNP during non-cardiac surgery.
Why the study?
In the perioperative setting, the genetic contribution to natriuretic peptide plasma level variability has not yet been determined.
Do NPPA/NPPB haplotypes impact BNP and NT-proBNP plasma levels in patients undergoing non-cardiac surgery?
Cohort (n=427)
Do NPPA/NPPB haplotypes impact BNP and NT-proBNP plasma levels in patients undergoing non-cardiac surgery?
Genetic variation in the NPPA/NPPB locus significantly impacts baseline BNP and NT-proBNP levels, suggesting genetic information could refine perioperative risk stratification thresholds.
No takes yet. Share an insight, caveat, or question.
NPPA/NPPB haplotypes were associated with natriuretic peptide levels; hypothesis-generating for genetic perioperative risk stratification.
Hahn et al. (2022) conducted a cohort in Patients presenting for non-cardiac surgery (n=427). NPPA/NPPB haplotypes vs. Reference haplotype TATAT was evaluated on BNP and NT-proBNP plasma concentrations. The NPPA/NPPB haplotype CACGC increased BNP and NT-proBNP plasma concentrations by 44% and 94%, respectively, compared to the reference haplotype TATAT in patients undergoing non-cardiac surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: