Key result
The rs198389 GG genotype in the NPPB promoter was associated with lower mortality (HR 0.86; 95% CI 0.78-0.95) and reduced hypertension compared with the AA genotype over a median 23 years.
Why the study?
Does the rs198389 GG genotype in the NPPB promoter associate with altered NT-proBNP levels, blood pressure, and mortality compared to the AA genotype in the general population?
Cohort (n=11,361)
Yes
Does the rs198389 GG genotype in the NPPB promoter associate with altered NT-proBNP levels, blood pressure, and mortality compared to the AA genotype in the general population?
Hazard Ratio: 0.86 (95% CI 0.78–0.95)
The rs198389 G allele in the NPPB promoter is associated with lifelong elevated NT-proBNP levels, lower blood pressure, reduced risk of hypertension, and decreased cardiovascular mortality.
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These genotype-outcome links should not yet alter practice; hypothesis-generating for causal NPPB studies in diverse cohorts.
Seidelmann et al. (2017) conducted a cohort in General population (n=11,361). rs198389 GG genotype vs. AA genotype was evaluated on Mortality (HR 0.86, 95% CI 0.78-0.95). The rs198389 GG genotype in the NPPB promoter was associated with lower mortality (HR 0.86; 95% CI 0.78-0.95) and reduced hypertension compared with the AA genotype over a median 23 years.
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