Genetic Variation in the Natriuretic Peptide System, Circulating Natriuretic Peptide Levels, and Blood Pressure: An Ambulatory Blood Pressure Study
Why the study?
Does genetic variation at the NPPB locus (rs632793) affect serum NT-proBNP concentrations and blood pressure levels measured by 24-h ABPMs versus OBPMs in healthy individuals?
Population
1,397 generally healthy individuals taking no blood pressure-lowering drugs
Comparison
rs632793 genotype at the NPPB locus (A:A genotype) vs rs632793 G:G genotype
Design
Cross-sectional
Authors
Discussion
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Implication
NPPB rs632793 A:A was associated with higher ambulatory BP despite lower NT-proBNP; leaves open causal role in hypertension, needs prospective validation.
Key Points
- This study aims to explore how genetic variations in the natriuretic peptide system affect blood pressure levels as measured by both ambulatory and office methods.
- Analyzed rs632793 at the NPPB locus in a sample of 1,397 healthy individuals not on blood pressure medication.
- Investigated correlations between genetically determined NT-proBNP concentrations and blood pressure levels using 24-h ABPM and OBPM measurements.
- Performed statistical analyses to compare serum NT-proBNP levels and blood pressure across genotypes.
- A significant correlation was found between rs632793 and serum NT-proBNP levels (r = 0.10, P = 0.0003).
- Participants with the A:A genotype exhibited lower NT-proBNP levels (34.8 pg/ml) compared to those with the G:G genotype (48.1 pg/ml), P = 0.0002.
- Individuals with the A:A genotype had higher 24-h ambulatory systolic (mean difference 2.0 mm Hg, P = 0.043) and diastolic blood pressure (mean difference 1.7 mm Hg, P = 0.011) compared to the G:G genotype.
Structured PICO
Does genetic variation at the NPPB locus (rs632793) affect serum NT-proBNP concentrations and blood pressure levels measured by 24-h ABPMs versus OBPMs in healthy individuals?
P
Population
1,397 generally healthy individuals taking no blood pressure-lowering drugs
I
Intervention
rs632793 genotype at the NPPB locus (A:A genotype)
C
Comparator
rs632793 G:G genotype
O
Outcome
Blood pressure levels determined by 24-h ambulatory blood pressure measurements (ABPMs) and office blood pressure measurements (OBPMs), and serum NT-proBNP concentrationssurrogate
Genetic variation at the NPPB locus is associated with differences in NT-proBNP levels and blood pressure, which are better detected by 24-hour ambulatory monitoring than office measurements.
Cite This Study
Jeppesen et al. (2012) studied this question.