What question did this study set out to answer?

To summarize recent discoveries in the molecular mechanisms of thyroid hormone biosynthesis, transport, and non-genomic signaling, and examine their diagnostic and therapeutic implications.

August 3, 2011Thyroid ResearchOpen Access

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

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Authors

KBKlaudia BrixUniversity of Bremen DFDagmar FührerEssen University Hospital HBHeike BiebermannHumboldt-Universität zu Berlin

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Implication

Narrative review reveals key molecular drivers of thyroid hormone synthesis and transport in humans, highlighting novel therapeutic targets for endocrine disorders.

Key Points

To summarize recent discoveries in the molecular mechanisms of thyroid hormone biosynthesis, transport, and non-genomic signaling, and examine their diagnostic and therapeutic implications.
Narrative review synthesizing molecular, genetic, and animal model research on thyroid hormone synthesis and cellular transport pathways.
Analysis of clinical and functional findings regarding mutations in transport proteins, biosynthetic genes, and novel thyroid hormone derivatives.
Mutations in biosynthesis proteins THOX2 and DEHAL cause variable degrees of hypothyroidism.
Defects in the T3 transporter monocarboxylate transporter 8 (MCT8) cause high serum T3 and severe X-linked intellectual disability in humans, whereas MCT8-deficient mice present with a mild phenotype.
Triiodothyronine triggers non-genomic actions through adhesion receptors, PI3K, and MAPK cascades, while newly identified decarboxylated derivatives (thyronamines) activate TAAR1 to reduce heart rate and body temperature.

Cite This Study

Brix et al. (2011) studied this question.

synapsesocial.com/papers/6a76fb07e29fd788c9f6f85d https://doi.org/10.1186/1756-6614-4-s1-s9

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Implication

Narrative review reveals key molecular drivers of thyroid hormone synthesis and transport in humans, highlighting novel therapeutic targets for endocrine disorders.

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives

Discussion

Member takes

Implication

Key Points

Cite This Study

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