December 1, 1988AJP Endocrinology and Metabolism
Contribution of the kidney to metabolic clearance of atrial natriuretic peptide
Population
Chronically instrumented one-kidney conscious dogs
Comparison
Synthetic alpha-human ANP- infused at 200 ng/min… vs The same dogs with a normally filtering kidney
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Does not inform ANP-based therapies in patients; leaves open whether peripheral clearance dominates in human cardiorenal disease.
Structured PICO
P
Population
Chronically instrumented one-kidney conscious dogs
I
Intervention
Synthetic alpha-human ANP-(1-28) infused at 200 ng/min to steady-state conditions with glomerular filtration rate (GFR) reduced to close to zero by acutely inflating a cuff around the renal artery (RAC)
C
Comparator
The same dogs with a normally filtering kidney
O
Outcome
Whole body metabolic clearance rate (MCR) and renal clearance rate (RCR) of ANPsurrogate
The kidney contributes only a small portion to the whole body metabolic clearance of atrial natriuretic peptide, which is primarily cleared by peripheral tissues.
Cite This Study
Robyn L. Woods (1988) studied this question.