Atrial natriuretic peptide in humans. Production and clearance by various tissues.
Why the study?
Does atrial pacing increase the secretion of atrial natriuretic peptide in humans?
Population
Patients undergoing cardiological investigation
Comparison
Stepwise incremental atrial pacing of up to 200… vs Baseline (before pacing)
Design
Other
Authors
Discussion
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Member takes
Implication
Supports cardiac ANP release with pacing; leaves open diagnostic or therapeutic roles in tachycardia or HF.
Structured PICO
Does atrial pacing increase the secretion of atrial natriuretic peptide in humans?
P
Population
Patients undergoing cardiological investigation
I
Intervention
Stepwise incremental atrial pacing of up to 200 beats per minute
C
Comparator
Baseline (before pacing)
O
Outcome
Immunoreactive atrial natriuretic peptide levels in coronary sinus, arterial, and venous bloodsurrogate
This study provides direct evidence that the human heart secretes atrial natriuretic peptide, which increases during atrial tachycardia and is cleared by peripheral organs.
Cite This Study
Crozier et al. (1986) studied this question.