Stability of the noninvasive baroreflex sensitivity assessment using cross‐spectral analysis of heart rate and arterial blood pressure variabilities
Why the study?
How do different body positions and breathing regimes influence noninvasive cross-spectral baroreflex sensitivity indices in patients with CAD and/or hypertension?
Population
103 patients (73 males, aged 53 +/- 12 years) with coronary artery disease and/or hypertension.
Design
Cross-sectional
Authors
Discussion
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Implication
Disagreement among noninvasive BRS indices warrants caution in clinical use across conditions; leaves open optimal standardization for reliable baroreflex assessment.
Key Points
- To evaluate how body position and breathing frequency influence noninvasive cross-spectral baroreflex sensitivity indices in low- and high-frequency bands.
- Evaluated 103 patients (73 males, mean age 53 ± 12 years) with coronary artery disease, hypertension, or both.
- Recorded simultaneous electrocardiography and noninvasive continuous blood pressure in supine and sitting positions during spontaneous, slow (0.1 Hz), and fast (0.33 Hz) breathing.
- Mean baroreflex sensitivity ranged from 5.0 ± 5.3 to 10.1 ± 7.9 ms/mmHg in the low-frequency band and from 6.6 ± 6.1 to 10.1 ± 7.9 ms/mmHg in the high-frequency band across tested conditions.
- Cross-method comparisons demonstrated marked disagreement, with systematic bias ranging from -1.0 to +0.7 ms/mmHg and limits of agreement spanning from ±1.7 to ±4.1 ms/mmHg.
Structured PICO
How do different body positions and breathing regimes influence noninvasive cross-spectral baroreflex sensitivity indices in patients with CAD and/or hypertension?
P
Population
103 patients (73 males, aged 53 +/- 12 years) with coronary artery disease and/or hypertension.
I
Intervention
Noninvasive baroreflex sensitivity assessment using cross-spectral analysis in supine and sitting positions during spontaneous, slow (0.1 Hz), and fast (0.33 Hz) controlled respiration.
O
Outcome
Cross-spectral baroreflex indices (coherence between the spectral densities of blood pressure and cardiac cycle variabilities) in low- and high-frequency bands.surrogate
BRS estimated in the low-frequency band in a sitting position during spontaneous respiration is the most representative measure of global baroreflex gain.
Cite This Study
Wichterle et al. (2000) studied this question.