What question did this study set out to answer?

To evaluate the safety and clinical efficacy of peripheral autologous bone marrow cell infusion in patients with decompensated liver cirrhosis.

June 16, 2006Stem Cells

Improved Liver Function in Patients with Liver Cirrhosis After Autologous Bone Marrow Cell Infusion Therapy

View Full Paper

Ask AI

Bookmark

Authors

STShuji TeraiNiigata University Medical and Dental Hospital TITsuyoshi IshikawaYamaguchi University KÔKaoru ÔmoriKashiwa Municipal Hospital

Discussion

Member takes

Implication

Clinical study demonstrates improved liver function and Child-Pugh scores in cirrhosis patients, indicating autologous bone marrow cell infusion is a viable therapy.

Key Points

To evaluate the safety and clinical efficacy of peripheral autologous bone marrow cell infusion in patients with decompensated liver cirrhosis.
Conducted an interventional study in N=9 liver cirrhosis patients with total bilirubin <3.0 mg/dl, platelet count >5 × 10¹⁰/l, and no viable hepatocellular carcinoma.
Harvested 400 ml of autologous bone marrow from the ilium, isolated mononuclear cells (MNCs) by cell washing, and infused 5.20 ± 0.63 × 10⁹ MNCs via peripheral vein.
Monitored liver function parameters over 24 weeks and analyzed pre- and post-treatment liver biopsy specimens.
Serum albumin levels and total protein demonstrated significant improvements at 24 weeks after cell infusion (p < .05).
Child-Pugh scores improved significantly at both 4 and 24 weeks post-treatment (p < .05), with no major adverse events observed.
Liver biopsy specimens showed significant elevation in alpha-fetoprotein and proliferating cell nuclear antigen expression post-infusion (p < .05).

Cite This Study

Terai et al. (2006) studied this question.

synapsesocial.com/papers/6a7702966c53f758bc1e76ca https://doi.org/10.1634/stemcells.2005-0542

View Full Paper

Ask AI

Bookmark

Implication

Clinical study demonstrates improved liver function and Child-Pugh scores in cirrhosis patients, indicating autologous bone marrow cell infusion is a viable therapy.

Improved Liver Function in Patients with Liver Cirrhosis After Autologous Bone Marrow Cell Infusion Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Improved Liver Function in Patients with Liver Cirrhosis After Autologous Bone Marrow Cell Infusion Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider