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May 1, 1989Journal of Biological ChemistryOpen Access

Identification of negative and positive regulatory elements in the human renin gene

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Population

Transient DNA transfer experiments with renin-chloramphenicol acetyltransferase fusions

Design

Preclinical

Authors

DBDavid W. BurtRoslin InstituteNNN. NakamuraNagasaki UniversityPKPamela KelleyStonehill College

Discussion

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Overview

No immediate clinical impact; leaves open functional validation and therapeutic targeting of renin regulatory elements.

Structured PICO

P
Population
Transient DNA transfer experiments with renin-chloramphenicol acetyltransferase fusions
I
Intervention
Mapping of DNA elements in the 5' flanking region of the human renin gene
O
Outcome
Identification of positive and negative control sequences

Identified specific enhancer, silencer, and cAMP-responsive elements in the 5' flanking region of the human renin gene, providing insight into its transcriptional regulation.

Cite This Study

Burt et al. (1989) studied this question.

synapsesocial.com/papers/6a7706df2e130d02afec5353https://doi.org/10.1016/s0021-9258(18)83241-0
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